The Barnsley-born youngster, who's last touch in a blue and white shirt was the winning goal against Hartlepool in the 2005 play-off final, will be laid low with a knee cartilage problem.
Talbot's luck has been miserable since that magic day in Cardiff - he missed the entire 2005/06 campaign with a back problem and picked up an injury when he returned to training earlier this month.
Paul Sturrock was hoping that he could call upon the striker for the opening match of the season against Preston or even tomorrow's game with Middlesbrough.
Meanwhile, David Graham has shocked Blackpool by not agreeing personal terms at Bloomfield Road and joined Bradford City on loan until the end of the year.